Isolated from IgA Nephropathy Patients Cells following Stimulation with IgA1 and Cell Proliferation in Human Mesangial Production of Proinflammatory Cytokines Spleen Tyrosine Kinase Is Important in the
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IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells.
BACKGROUND Circulating immune complexes (CIC) containing galactose (Gal)-deficient IgA1 from adults with IgA nephropathy (IgAN) induce proliferation of cultured mesangial cells, but activities of CIC from pediatric patients with the disease have not been studied. METHODS CIC of different sizes were isolated from sera of pediatric and adult IgAN patients and their effects on cultured human mes...
متن کاملThe glomerular response to IgA deposition in IgA nephropathy.
Compelling evidence points to a role for IgA receptors in the pathogenesis of IgA nephropathy. The soluble form of the type I IgA receptor (FcalphaRI or CD89) forms complexes with IgA that can be found in patients' serum and that initiate the disease in CD89 transgenic mice. A nonclassic IgA receptor, identified as the transferrin receptor (TfR), is highly expressed in patients' mesangium and c...
متن کاملProliferation and Cytokine Production of Human Mesangial Cells Stimulated by Secretory IgA Isolated from Patients with IgA Nephropathy.
BACKGROUND/AIMS IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, and often aggravates by mucosal infection. Secretory IgA (SIgA) is the dominant immunoglobulin in mucosal immunity, and is deposited in the mesangium in IgAN. The biological effects of SIgA on mesangial cells are poorly understood. METHODS Deposition of SIgA in frozen renal sections from IgAN patient...
متن کاملCCL20 secreted from IgA1-stimulated human mesangial cells recruits inflammatory Th17 cells in IgA nephropathy
IgA nephropathy (IgAN) is the most common primary glomerulonephritis characterized by human mesangial cells (HMC) proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient IgA1. However, how IgA1 contributes to IgAN has yet to be completely elucidated. In this study, the expression profile of chemokines was more altered in IgA1-treated HM...
متن کاملThe possible involvement of intestine-derived IgA1: a case of IgA nephropathy associated with Crohn’s disease
BACKGROUND A link between IgA nephropathy and Crohn's disease has recently been reported. Other researchers hypothesize that intestine-derived IgA complexes deposit in glomerular mesangial cells, eliciting IgA nephropathy. Intestinal mucosal plasma cells mainly secrete IgA2. Nevertheless, IgA1 deposition is strongly implicated as being the primary cause of IgA nephropathy. CASE PRESENTATION A...
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تاریخ انتشار 2012